Trimethylaminuria Disease Information

Trimethylaminuria (TMAU) is a rare metabolic disorder that impairs the body's capacity to break down some compounds, including trimethylamine (TMA), which is created in the gut and normally degraded by the liver. Individuals with TMAU are unable to break down TMA, leading to an accumulation of the compound in the body. This buildup of TMA results in a strong, fish-like body odor, especially when the person perspires. TMAU is caused by a hereditary genetic mutation that affects an enzyme known as flavin-containing monooxygenase 3 (FMO3). This enzyme is responsible for breaking down TMA and other compounds. When the FMO3 enzyme is not functioning properly, the body is unable to break down TMA, causing the buildup of the compound and the fishy body odor. TMAU is identified through a combination of genetic testing and laboratory tests. Treatment usually involves a low-protein diet and dietary supplements that can aid in reducing the production of TMA. In some cases, antibiotics or other medications may be prescribed to help reduce the production of TMA. Living with TMAU can be difficult, as the fishy odor can be a source of shame and social discrimination. People with TMAU may also feel isolated and may find it hard to form relationships. Nevertheless, with proper management, people with TMAU can lead full and active lives.

1. Primary Trimethylaminuria
2. Secondary Trimethylaminuria
3. Genetic Trimethylaminuria
4. Acquired Trimethylaminuria
5. Congenital Trimethylaminuria

1. Body odor that smells like fish, garbage, or rotting eggs
2. Urine that smells like fish
3. Breath that smells like fish, garbage, or rotting eggs
4. Sweat that smells like fish, garbage, or rotting eggs
5. Feeling of nausea or loss of appetite
6. Skin irritation or rash
7. Fatigue or low energy levels
8. Anxiety or depression
9. Low self-esteem or social isolation
10. Difficulty concentrating or focusing

Trimethylaminuria is usually identified with a urine examination to determine amounts of trimethylamine (TMA) in the urine. Other tests may include a blood test to assess amounts of TMA, a genetic test to search for changes in the FMO3 gene, and a breath test to measure amounts of TMA in the breath.

Trimethylaminuria (TMAU) is a rare metabolic disorder which leads to an unpleasant body odour. It is a result of a genetic mutation which impedes the body's capability to break down the chemical trimethylamine (TMA), which is created in the gut when particular foods are processed. People suffering from TMAU have an accumulation of TMA in their bodies, which is emitted through sweat, urine, and breath, causing a very strong, fishy smell.

Trimethylaminuria is managed with dietary alterations, antibiotics, and activated charcoal. Dietary alterations involve steering clear of edibles high in trimethylamine, such as fish, eggs, legumes, and some vegetables. Antibiotics can be prescribed to reduce the amount of bacteria in the bowels that generate trimethylamine. Activated charcoal can be taken to absorb trimethylamine in the intestine prior to it being emitted into the body. In some cases, trimethylaminuria may be dealt with medications that inhibit the production of trimethylamine, such as trimethoprim or metronidazole.

1. Remain optimistic: Trimethylaminuria can be a difficult state to cope with, but it is essential to maintain an upbeat attitude and concentrate on the things you can do to control the condition.
2. Recognize your triggers: Keeping a food log can help you pinpoint which foods may cause your symptoms.
3. Exercise frequently: Exercise can assist in improving your overall health and well-being, in addition to decreasing stress, which can help control your symptoms.
4. Take dietary supplements: Certain dietary supplements, such as activated charcoal and magnesium, can help reduce the scent linked to trimethylaminuria.
5. Consult your physician: Your doctor can help you manage your symptoms and find the most suitable treatment plan for you.
6. Join a support network: Joining a support network can be a great way to associate with other people who are living with trimethylaminuria and swap stories.